Lumpectomy is the preferred surgical treatment for women diagnosed with early-stage breast cancer. At this stage, the cancerous tissue only forms a small portion of the breast and during lumpectomy, the surgeon removes this portion of the breast along with some surrounded healthy tissue to assure the complete resection of the tumor and meanwhile satisfactory cosmetic outcomes. On the surgical side, the tumor and healthy breast tissue cannot always be clearly distinguished, making it difficult for the surgeon to determine where to dissect the tissue. Difficulty in detecting the border of the tumor in lumpectomy can result in incomplete tumor resection which only can be determined by histopathological investigation of the excised specimens after the surgery. In this case, the treatment of the patient may continue with a re-excision surgery or extra chemotherapy. Using an intraoperative margin assessment technique during lumpectomy could help the surgeon with detecting the border of the tumor and distinguish it from the breast’s healthy tissue. Among different type of techniques, diffused reflectance spectroscopy (DRS) has recently become known as a promising tumor detection technique and has been widely studied for its application in this field. Recently we studied the possibility of integrating an electrosurgical knife with a DRS system to provide the surgeon with real-time oncological guidance during the lumpectomy. To find the optimum design of the smart surgical knife we are looking for an enthusiastic MSc student who can come up with creative design ideas.
If you are interested in designing surgical instruments and preferably have a background in mechanical design, then you are the right person for this MSc project/assignment. For more information please contact Sara Azizian Amiri, firstname.lastname@example.org.
This research project is part of the MEDPHOT programme and is funded by the Netherlands Organization for Scientific Research NWO. The MEDPHOT programme, carried out bij a consortium of Dutch Universities, university medical centres, and companies, aims to develop new optical biomarkers that are needed to realise earlier diagnosis, improved treatment and better quality of life in the fields of oncology, asthma, and neurodegeneration.
The standard surgical treatment of prostate cancer is radical prostatectomy. However, side effects of radical prostatectomy are incontinence and erectile dysfunction. A local treatment that preserves noncancerous tissue like focal laser ablation reduces these side effects. Focal laser ablation is an optical fibre-based laser ablation treatment that allows for fast percutaneous focal ablation of prostate tumours. Using needles and magnetic resonance imaging (MRI)-guidance, the medical operator can position optical fibres at the target region. However, for ablation to be successful, it is important to have full positioning control over the accuracy and extend of the ablation.
This research aims to develop an MRI in-bore ready steerable needles to position the optical treatment fibre at the target region. A novel actuation system will allow for safe use inside the MRI scanner. The integration of the steerable needle, the novel actuation system, and a laser ablation fibre will make the needle suitable for use under MRI guidance to enable precise ablation of the prostate tumour.
Spinal fusion is the surgical procedure of stiffening parts of the spinal column to reduce back pain for patients affected by multiple diseases. At the BITE group, we are developing a novel drill that allows for the surgeon to steer through the bone along a secure drilling trajectory, avoiding nerves and blood vessels that run along the spinal column.
To help the surgeon find and maintain the right trajectory, an optical sensing system based on Diffuse Reflectance Spectroscopy (DRS) will be integrated into the drill to differentiate the tissue ahead of the tool tip, thereby providing positional feedback for the surgeon in real time.
In the scope of the proposed graduation project, a bone tissue-simulating phantom will be designed that mimics both mechanical and optical properties of human bone. This phantom will allow for mechanical testing of the steerable drill, as well as for optical testing of the sensing system. Eventually, it will also provide a training environment where surgeons can become accustomed to the novel tool.
This assignment will be available from March/April 2021. Interested? Contact Merle Losch, email@example.com.
During complex surgical procedures such as in skull-base surgery, there is a need to reach difficult-to-reach locations via narrow anatomic corridors. Performing surgery along complex 3D pathways requires a snake-like instrument that memorizes the 3D shape of the followed pathway and shifts the shape backward as the instrument moves forward. This snake-like method of locomotion is called “follow-the-leader locomotion”, in which the head is the “leader” and the body follows the pathway of the head, see the following animations:
Follow-the-leader locomotion requires a segmented multi-steerable instrument as well as a memory in which the angles of the segments can be stored and shifted. In robotic approaches, the actuation occurs by a range of electric motors controlled by a computer. Although feasible, this will result in a very complex system requiring additional safety measures to ensure reliability during surgery.
In a desire to create a simpler system, we explored an alternative follow-the-leader approach by using a mechanical memory. Following our HelicoFlex design, the MemoFlex II contains an Ø8 mm multi-steerable tip with 14 segments controlled by 56 steering cables in 28 Degrees of Freedom. The novel compliant frame of the tip is entirely non-assembly 3D printed out of one single part, creating an easy-to-make construction with a large range of snake-like motion possibilities.
The mechanical shape memory consists of four 3D printed plates (two for the horizontal plane and two for the vertical plane) containing curved grooves representing the required pathway of the tip. The four plates are mounted in a rotatable blue cylinder that is surrounded by a static exoskeleton. When the instrument is moved forward, the cylinder turns around, driven by a cam in the exoskeleton, and the curved grooves move along a set of ball bearings, each bearing connected to one of the steering cables, causing the tip to move along the shape of the curved grooves. The pre-programmed groove-shape can be derived preoperatively from CT or MRI-images.
Imagine a tower build of LEGO, consisting of a number of bricks that together form a new shape. Now imagine that each LEGO brick is a tiny mechanism, in contact with the mechanisms that surround it. What if we can program each individual mechanism with a very simple task, and are able to turn it on or off when we desire. Could we use these tiny mechanisms as cells that create a new, larger mechanism? Can we create a mechanism that is a lawnmower one day, a coffee machine the next, just by switching on or off certain cells?
We want to use the form complexity of 3D printing to create ‘hierarchical mechanisms’, closely related to metamaterials. This is an exploratory assignment, so we are looking for a creative student with an investigative, curious mind. Some inspirational work is shown on this page.
Interested? This assignment is available starting January/February 2021. Contact Kirsten Lussenburg, firstname.lastname@example.org.
Surgical instruments used in eye surgery are very small, which makes it difficult to produce instruments with high functionality. The bottleneck in the production of eye surgical instruments is the assembly step. Assembly has to be done by hand, because of the small size of the parts. Automation is difficult to implement, due to the relatively small number of specific instruments. As a solution to this problem, the complexity offered by 3D printing can be used. A way to do this is to 3D print entire functioning products or mechanism in one single step, without the need of assembling them afterwards, called non-assembly 3D printing.
A vitrectome is a specific instrument used in eye surgery to remove the vitreous from the eye. It consists of two thin, hollow needles that are inserted into the eye, and a handle containing a vibrating mechanism. In this assignment, you will be working on the design of a non-assembly 3D printed vitrectome mechanism, which should have the same specifications as current vitrectomes.
This assignment will be available from January/February 2021. Interested? Contact Kirsten Lussenburg, email@example.com.
During spinal fusion surgery multiple vertebrae are fused by fixating them together with an internal brace. The brace is connected to a vertebra with pedicle screws. The inside of the bone (cancellous bone) is too weak to achieve sufficient grip. Therefore, screw fixation mainly relies on locations where the screw is in direct contact with the surrounding layer of the much harder cortical bone. We are developing a steerable bone drill in order to increase the contact area of screws and cortical bone by drilling along the cortical bone layer. An optical sensing system that can differentiate the two types of bone tissue will help the surgeon find and maintain the right drilling trajectory. Furthermore, a novel anchoring device that is flexible during insertion, but becomes rigid once in place will replace straight pedicle screws.
There are multiple graduation projects available related to optical sensing, bone drilling and anchoring.
Development of a bone phantom for testing of a steerable drill or screw Contact: Merle Losch,firstname.lastname@example.org
Design of a drill prototype to provide directional feedback Contact: Merle Losch,email@example.com
Design of flexible screw that can become incredibly stiff in order to transfer the forces acting of the screw Contact: Esther de Kater, firstname.lastname@example.org
Design of a flexible screw that adheres to the bone surface in order to transfer the forces acting on the screw Contact:Esther de Kater, email@example.com
In minimally invasive surgery, instrument maneuverability is limited by the use of small incisions. Increasing the number of degrees of freedom (DOF) of the instrument shaft is beneficial for many surgical interventions. However, increasing DOF usually leads to high mechanical complexity, issues with sterilisation and too large cost price for disposable use.
In an attempt to reduce manufacturing time we propose the first fully 3D-printed handheld, multi-steerable instrument: the HelicoFlex. The instrument is mechanically actuated and is fitted with a compliant shaft containing five serially-controlled segments enabling high maneuverability in 10 degrees of freedom.
Our new, compliant segment design merges the functions of four helicoids and a continuum backbone combining high torsion and axial stiffness with low bending stiffness. Five such compliant segments were combined to form the shaft of the HelicoFlex. Following the control design strategy of our older MultiFlex and HelixFlex devices, a compliant control handle was designed that mimics the shaft structure.
The entire frame of the HelicoFlex consists of only three complex-shaped 3D printed components that are printed without a need for any support material in the compliant section. The use of minimal-assembly 3D printing drastically decreases assembly time. Our 3D printed shaft features four working channels that facilitate combined use with flexible instruments such as biopsy forcipes. With its 10 degrees of freedom, our HelicoFlex showed a fluid motion in performing single and multi-curved paths.
A wasp ovipositor is a needle-like structure composed out of three elements, called valves. A female wasp uses this structure to drill into wood or fruit to deposit eggs inside a living host. The propagation of the ovipositor through the substrate is achieved by a push-pull mechanism, in which one of the valves is pushed while the other two are pulled.
Inspired by the ovipositor of parasitoid wasps, we developed a novel self-propelling Ovipositor Device designed for locomotion through the large intestine (colon). The device contains a miniature electric motor connected to a cylindrical cam. Six sliders are placed around the cam and move forward and backward following the path defined by the cam. Designed for motion through soft environments, the working principle of the propulsion mechanism is that multiple stationary sliders create sufficient friction to allow for a single slider to shuffle forward. In each step, one slider moves forward whereas the others remain stationary relative to the environment, generating a smooth and continuous motion at approximately 1/6 of the speed of a moving slider. The ovipositor mechanism allows a simple and robost construction that can be easily miniaturised to very small dimensions, see our research on self-propelled ovipositor needles.
Experiments were carried out with various flexible 3D-printed structures attached to the outer surface of each slider to generate direction-dependent friction for further enhancement of grip. Tests in plastic tubes showed fast and fluent self-propelled motion. Locomotion in a colon was succesfully achieved with an improved 3D-printed outer surface in which the tangential spacing between the sliding structures was decreased so that the colonic wall does not flex between them. The improved prototype was able to self-propel ex-vivo through a porcine colon without any visual damage to the colonic wall.
This research project is funded by the Netherlands Organization for Scientific Research NWO and conducted in collaboration with Philips Research, DEAM, Karolinska University Hospital in Sweden, Amsterdam University Medical Center and Reinier de Graaf Hospital in Delft.
Spinal fusion is the surgical procedure of stiffening parts of the spinal column with screws and rods to, among others, reduce back pain for patients affected by multiple diseases. Vertebrae have an outer layer of hard cortical bone surrounding the softer core that consists of cancelous bone. The strength of the connection between vertebra and screw mainly relies on the contact area with the cortical bone, but drilling close to this cortical bone layer is risky, as it can lead to cortical breaches. These breaches can have severe complications, especially since important neural and vascular structures run along the spinal column.
This research will focus on creating a better fixation of the screws and preventing complications that can arise due to cortical breaches by developing a steerable bone drill with an optical sensing system in the tip. This allows the surgeon to drill a curved path along the cortical bone layer while getting real time information about the location of the drill. Regular stiff screws will not fit this curved hole, thus a new anchoring device will be developed that is flexible when introduced to the curved hole and that can become rigid to generate the needed fixation.
Solving medical problems through nature’s ingenuity